Effect of T-activin on thymocyte reproduction and migration

Autor:	Arion VIa, Lindner Dp, Krotova Sk, Aleĭnikova Nv, Baryshkov IuA
Rok vydání:	1983
Předmět:	medicine.medical_specialty media_common.quotation_subject Microgram General Medicine Single injection Biology General Biochemistry Genetics and Molecular Biology Cortex (botany) Thymocyte Endocrinology Internal medicine Parenchyma medicine Reproduction media_common
Zdroj:	Bulletin of Experimental Biology and Medicine. 95:513-516
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00838875
Popis:	Forty seven F1 (CBA X C57Bl) mice were used for quantitative morphologic examination of the thymus on 1, 5, 10 and 15 days after a single injection of 0.5 microgram T-activin, and injections of 0.1 microgram of T-activin once a day during 5 days. The number of transformed thymocytes and mitoses figures in cortex was found to be increased reaching a maximum at the 5th day as regards the magnitude and spreading. By the end of the research the number of transformed thymocytes and mitoses returned to initial values. There was a periodical (at the 5th and 10th days) 1 mm2 reduction in the number of thymocytes, an increase in the proportion of medullary thymocytes, reaching maximum at the 5th day, and a tendency towards the reduction of a relative area of the parenchyma. These indicators did not return to the initial values by the 15th days. However there was a tendency towards normalization. The conclusion is made about the stimulatory effect of T-activin on reproduction and migration of thymocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6877fa6e5722d5df8f9a9f1848709cb8 https://doi.org/10.1007/bf00838875 Zobrazit plný text záznamu Full text from SpringerLink