Differential Effects of Cyclophosphamide on the B and T Cell Compartments of Adult Mice

Autor:	Gail D. Stockman, Lyle R. Heim, Mary Ann South, John J. Trentin
Rok vydání:	1973
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 110:277-282
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.110.1.277
Popis:	Adult mice were given a single sublethal dose of cyclophosphamide. Effects of the drug on the bone marrow-derived (B) and thymus-derived (T) cell compartments were measured by studies on lymphocyte transformation, lymphoid tissue morphology and responsiveness to a primary injection of keyhole limpet hemocyanin. These studies indicated that the effect of cyclophosphamide on the B cell compartment was more severe and longer-lasting than the effect on the T cell compartment.
Databáze:	OpenAIRE
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