Rh(I)-Catalyzed Asymmetric Intramolecular Pauson-Khand Reaction in Aqueous Media

Autor:	Sang Ick Lee, Won Hyuck Suh, Mira Choi, Young Keun Chung
Rok vydání:	2003
Předmět:	Aqueous solution Pauson–Khand reaction Organic Chemistry Enantioselective synthesis chemistry.chemical_element Substrate (chemistry) Medicinal chemistry Catalysis Rhodium chemistry.chemical_compound chemistry Intramolecular force BINAP
Zdroj:	Synthesis. :2169-2172
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-2003-41044
Popis:	The first rhodium-BINAP complex-catalyzed enantioselective Pauson-Khand reaction in aqueous media, which is accelerated by surfactant, is reported. The chiral rhodium catalyst is easily prepared in situ from I equivalent of [Rh(cod)Cl] 2 and 2 equivalents of BINAP under I atm of CO and a temperature of 60 °C or 90 °C. Ee's up to 96% were achieved for the intramolecular Pauson-Khand reaction, but the yields are highly dependent upon the substrate itself.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6873a85d0cf53201d800cd3e0913443e https://doi.org/10.1055/s-2003-41044 Zobrazit plný text záznamu