Structure-Dependent Development of the Antihypoxic Activity of Benzothiazole Derivatives Under Hypoxic Conditions of Various Etiologies

Autor:	V. V. Yasnetsov, O. A. Kh. Almukhtar, M. V. Troshina, N. F. Petukhova, I. N. Krylova, E. G. Tsublova
Rok vydání:	2020
Předmět:	Pharmacology chemistry.chemical_classification chemistry.chemical_compound chemistry Benzothiazole Stereochemistry Drug Discovery Pharmacology toxicology Substituent Molecule Male mice Organic acid
Zdroj:	Pharmaceutical Chemistry Journal. 54:335-339
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-020-02201-2
Popis:	The antihypoxic activities of new benzothiazole derivatives were studied in experiments on outbred male mice. The effects were found to be directly determined not only by the type of substituent on the heterocycle but also the organic acid in the molecule. The most pronounced effect was observed for molecules containing a succinate fragment.
Databáze:	OpenAIRE
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