Automatic, sterile, and apyrogenic delivery of PET radiotracers from the cyclotron to the patient

Autor: D.B. Cashion, J.R. Votaw, J.A. Clanton
Rok vydání: 1991
Předmět:
Zdroj: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. :1214-1217
ISSN: 0168-583X
Popis: An automatic delivery remote injection system has been developed to administer either 13 N-labelled ammonia, or 15 O-labelled water or 18 F-labelled FDG to patients. Automation increases the throughout and efficiency of the PET center, and remote dose administration ensures patient safety and reduces the radiation exposure to the technologist supervising the radiopharmaceutical injection. The remote dose administration apparatus utilizes a syringe pump to transfer liquid activity and a solenoid three-way valve to switch between lines connected to a patient and a receiving vial. To ensure apyrogenicity and sterility of the injected product, the entire system is washed with sterile water before it is used. Since the tracer is delivered in an ~ 8 ml bolus of water, the next delivery through the system is considered safe for injection if pyrogens are not detected at a threshold of 3 endotoxin units per ml (EU/ml) in the wash. Time delayed tests shows that the system may be left unused for up to 6 h before the wash must be repeated.
Databáze: OpenAIRE