Neurotoxicity of Copper
| Autor: | Ivo F. Scheiber, Felix Bulcke, Ralf Dringen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Copper oxide nanoparticles Copper toxicity Neurotoxicity chemistry.chemical_element medicine.disease medicine.disease_cause Copper Cell biology Copper homeostasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine chemistry Toxicity medicine Copper deficiency 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Advances in Neurobiology ISBN: 9783319601885 |
| DOI: | 10.1007/978-3-319-60189-2_16 |
| Popis: | Copper is an essential trace metal that is required for several important biological processes, however, an excess of copper can be toxic to cells. Therefore, systemic and cellular copper homeostasis is tightly regulated, but dysregulation of copper homeostasis may occur in disease states, resulting either in copper deficiency or copper overload and toxicity. This chapter will give an overview on the biological roles of copper and of the mechanisms involved in copper uptake, storage, and distribution. In addition, we will describe potential mechanisms of the cellular toxicity of copper and copper oxide nanoparticles. Finally, we will summarize the current knowledge on the connection of copper toxicity with neurodegenerative diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|