Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study
| Autor: | Branislava Kocić, Dragoljub L. Miladinović, Dobrila M. Stankovic Dordevic, Marija Marković, Marija V. Dimitrijevic |
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| Rok vydání: | 2020 |
| Předmět: |
Process equipment
biology Chemistry Materials Science (miscellaneous) Process Chemistry and Technology General Engineering General Chemistry General Medicine Helicobacter pylori biology.organism_classification General Biochemistry Genetics and Molecular Biology Natural (archaeology) Petrochemistry Materials Chemistry Biochemical engineering General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Revista de Chimie. 71:267-273 |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.20.6.8192 |
| Popis: | The susceptibility of Helicobacter pylori to three essential oils (EOs), 12 naturally occurring monoterpene hydrocarbons, oxygenated and phenolic monoterpenes and three reference antibiotics were studied. Classification and comparison of essential oils and monoterpenes on the basis of their chemical composition and antibacterial activity were made by the utilization of principal component analyses (PCA) and agglomerative hierarchical clustering (AHC). The most abundant compound in the Thymus glabrescens Willd. and Thymus pulegioides L. EOs is geraniol (33.8% and 52.5%), while the main constituent in Satureja kitaibelii Wierzb. ex Heuff. EO is limonene (16,1%). The compound that was the most active against H. pylori was carvacrol. EOs of T. glabrescens and S. kitaibelii exhibit higher antibacterial ability in comparison with all monoterpenes, except carvacrol, probably based on the concept of synergistic activity of essential oil components. PCA separated essential oils based on chemical composition and explain 96.5% of the total variance in the first two principal components. Essential oils, phenolic monoterpenes and two antibiotics were classified in the same sub-cluster within AHC analyses. EOs of T. glabrescens and S. kitaibelii can be used to treat infections caused by H. pylori, as a potentially effective, cheap and safe natural products. Further research of antibacterial activity of selected monoterpenes, essential oils and standard antibiotic combinations, as well as clinical study are required. |
| Databáze: | OpenAIRE |
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