The Dynamics of Neutralizing Antibody Level in One Year After SARS-CoV-2 Infection

Autor: An'an Li, Mingxing Huang, Zhongqiang Ren, Xingfei Pan, Rutian Zheng, Yufeng Liang, Huiyi Lu, Tao Wang, Changwen Ke, Xionghui Cai, Guanting Zhang, Wenshan Hong, Jinyu Xia, Mengdang Ou, Jiahui Lu, Dan Liang
Rok vydání: 2021
Předmět:
Popis: Background: A lot of recent researches have focused on the duration of the nature immunity elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. An improved understanding of the immunity offered by the antibodies developed against SARS-CoV-2 in recovered patients is critical for the development of diagnostic tests and vaccines. Methods: We enrolled 114 donors, which providing blood samples after discharge for half a year and one year. Neutralizing antibodies (NAbs) were tested using a micro-neutralization assay. Results: In two tests, 82 of 114 recovered patients completed the first test half a year after discharge and NAbs remained detectable in the vast majority of patients (75/82, 91.46%). In the comparison of the two intervals, 50% (27/54) of individuals had increased NAbs titers. when 31.48% (17/54) of patients remained unchanged. Conclusion: Our results suggest that immune ability is acquired in most individuals infected with SARS-CoV-2 and is sustained in a majority of patients for up to a year after recovery.
Databáze: OpenAIRE