An Unprecedented Pseudo-[3+2] Annulation between N -(4-Methoxyphenyl)aldimines and Aqueous Glutaraldehyde: Direct Synthesis of Pyrrole-2,4-dialdehydes

Autor:	Nisar A. Mir, Panduga Ramaraju, Deepika Singh, Preetika Sharma, Rajni Kant, Indresh Kumar
Rok vydání:	2017
Předmět:	chemistry.chemical_classification Aldimine Annulation Aqueous solution 010405 organic chemistry Organic Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Organocatalysis Organic chemistry Glutaraldehyde Physical and Theoretical Chemistry Mannich reaction Pyrrole
Zdroj:	European Journal of Organic Chemistry. 2017:3461-3465
ISSN:	1434-193X
DOI:	10.1002/ejoc.201700500
Popis:	A new method for the direct one-pot synthesis of substituted pyrrole-2,4-dialdehdyes is developed. This overall pseudo-[3+2] annulation reaction between glutaraldehyde and N-PMP-aldimines (PMP = p-OMeC6H4) proceed through proline-catalyzed direct Mannich reaction/ cyclization, followed by IBX-mediated oxidative rearrangement of in situ generated intermediate compound to pyrrole-2,4-dialdehydes with high yields (up to 80%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::686122fc74abb3ab0c9b1225ddb8c8f2 https://doi.org/10.1002/ejoc.201700500 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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