Saxifraganoids A and B, two novel cucurbitane triterpenoid glycosides from Saxifraga umbellulata var. pectinata
| Autor: | Yao Fei, Xiaolang Du, Bo Li, Shou-Wen Zhang, Guoyue Zhong, Wei Jiang, Zejing Mu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry Stereochemistry Organic Chemistry Glycoside Cucurbitane biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Acetylglucosamine 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Triterpenoid chemistry Drug Discovery Carbon tetrachloride Two-dimensional nuclear magnetic resonance spectroscopy Saxifraga umbellulata |
| Zdroj: | Tetrahedron Letters. 58:3541-3544 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.07.093 |
| Popis: | Two novel cucurbitane triterpenoid glycosides, named saxifraganoids A ( 1 ) and B ( 2 ), were isolated from Saxifraga umbellulata var. pectinata . Their structures including absolute configurations were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HRMS), and single-crystal X-ray diffraction. Compound 1 represents the first example of cucurbitane triterpenoid with a Δ 17(20) , and compound 2 contained an unusual N -acetylglucosamine at C-16. The protective effects against liver injury induced by carbon tetrachloride (CCl 4 ) in the human embryonic-liver L-02 cells of these two compounds were evaluated. |
| Databáze: | OpenAIRE |
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