Synthesis, characterization and DNA-binding properties of mixed porphyrin?polypyridyl ruthenium(II) complexes

Autor:	Kang C. Zheng, Wen J. Mei, Jun Li, Ying X. Liu, Jie Liu, Liang N. Ji
Rok vydání:	2005
Předmět:	Ligand Stereochemistry Metals and Alloys Ab initio chemistry.chemical_element Dihedral angle Porphyrin Ruthenium Inorganic Chemistry Crystallography chemistry.chemical_compound chemistry Materials Chemistry Density functional theory Cyclic voltammetry Organometallic chemistry
Zdroj:	Transition Metal Chemistry. 30:82-88
ISSN:	1572-901X 0340-4285
DOI:	10.1007/s11243-004-3047-6
Popis:	Two mixed porphyrin–polypyridyl RuII complexes [Ru(bpy)2(MPyTPP)Cl]Cl (1) and [Ru(phen)2(MPyTPP)Cl]Cl ( 2 ) (bpy=2,2′-bipyridine; phen=1,10-phenanthroline; MPyTPP=5-monopyridyl-10,15,20–triphenylporphyrin) have been synthesized and characterized by elementary analysis, e.s.–m.s., cyclic voltammetry and u.v.–vis. spectroscopy. The DNA-binding properties of these complexes were investigated by electronic spectra, c.d. spectra and viscosity experiments. The results suggested that both complexes (1) and (2) bind to DNA in an outside binding mode. At the same time, theoretical calculations applying the ab initio and the density functional theory (DFT) methods were also performed, and the results showed that there is no good planarity on the main ligand MPyTPP of these complexes, and there are rather great distortion angles (dihedral angles ca. 72°) between the porphrin ring and each of the 10-, 15-, 20-phenyl groups. This may be the reason why the complexes bind to DNA in an outside mode, instead of an intercalative mode.
Databáze:	OpenAIRE
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