| Popis: |
This chapter highlights how to make smart use of several good animal models. However, these animal experiments must be augmented with human-based in vitro experiments, good toxicity databases, and computer modeling technology. Differences in animal and human cells do result in differences in the efficacy and toxicology of certain drugs. The old industrial adage does hold true for the development of drugs and other therapeutics–“cheaper, faster, better.” As will be shown here, it is accomplished by the use of computer models, in vitro testing using human cells or cell lines, and gold standard animal models, before human trials begin. Keywords: animal models; human-based in vitro experiments; computer modeling; knockouts; transgenic models; immunomodulation |
