Evaluation of magnetic resonance imaging for the differentiation of inflammatory, neoplastic, and vascular intradural spinal cord diseases in the dog
| Autor: | Annie V. Chen, Theresa E. Pancotto, Marc Kent, Shannon P. Holmes, John F. Griffin, Silke Hecht, Simon R. Platt, Joseph M. Mankin, Amanda E. Masciarelli, Jonathan M. Levine, Geoffrey T. Fosgate |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Degenerative myelopathy General Veterinary medicine.diagnostic_test 040301 veterinary sciences business.industry Magnetic resonance imaging Spinal Cord Diseases 04 agricultural and veterinary sciences Spinal cord 030218 nuclear medicine & medical imaging 0403 veterinary science 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Clinical information medicine Tumor type Medical diagnosis business |
| Zdroj: | Veterinary Radiology & Ultrasound. 58:444-453 |
| ISSN: | 1058-8183 |
| DOI: | 10.1111/vru.12501 |
| Popis: | Magnetic resonance imaging (MRI) is a common test for dogs with suspected intradural spinal cord lesions, however studies on diagnostic performance for this test are lacking. Objectives of this multi-institutional, retrospective, case-control study were to estimate sensitivity and specificity of MRI for (1) distinguishing between histopathologically confirmed intradural spinal cord disease versus degenerative myelopathy in dogs, (2) categorizing intradural spinal cord diseases as neoplastic, inflammatory, or vascular; and (3) determining tumor type within the etiologic category of neoplasia. Additional aims were to (1) determine whether knowledge of clinical data affects sensitivity and specificity of MRI diagnoses; and (2) report interrater agreement for MRI classification of intradural spinal lesions. Cases were recruited from participating hospital databases over a 7-year period. Three reviewers independently evaluated each MRI study prior to and after provision of clinical information. A total of 87 cases were sampled (17 degenerative myelopathy, 53 neoplasia, nine inflammatory, and eight vascular). Magnetic resonance imaging had excellent (>97.6%) sensitivity for diagnosis of intradural spinal cord lesions but specificity varied before and after provision of clinical data (68.6% vs. 82.4%, P = 0.023). Magnetic resonance imaging had good sensitivity (86.8%) and moderate specificity (64.7-72.5%) for diagnosing neoplasia. Sensitivity was lower for classifying inflammatory lesions but improved with provision of clinical data (48.1% vs. 81.5%, P = 0.015). Magnetic resonance imaging was insensitive for diagnosing vascular lesions (25.0%). Interrater agreement was very good for correctly diagnosing dogs with intradural lesions (ĸ = 0.882-0.833), and good (ĸ = 0.726-0.671) for diagnosing dogs with neoplasia. |
| Databáze: | OpenAIRE |
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