Impact of early post-stress 99mTc sestamibi ECG-gated SPECT myocardial perfusion imaging on the detection of ischemic LV dyssynchrony: an early step in the stunning cascade

Autor: Claudia Mariana Cortés, E. Natalia Aramayo G, Paula Elizabeth Barboza, Alberto Crottogini, Mario Alberto Embon
Rok vydání: 2021
Předmět:
Zdroj: The International Journal of Cardiovascular Imaging. 37:1789-1798
ISSN: 1573-0743
1569-5794
DOI: 10.1007/s10554-020-02145-4
Popis: Transient alterations in ventricular conduction and synchronized cardiac performance have been reported in experimental models of myocardial ischemia. In post-stress 99mTc-sestamibi-gated-SPECT myocardial perfusion imaging (MPI), the time elapsed between tracer injection and image acquisition could influence the detection of ischemic left ventricular mechanical dyssynchrony (LVMD). We aimed at evaluating whether early vs. delayed post-stress MPI improve ischemic LVMD detection using the phase analysis parameters standard deviation (SD) and histogram bandwidth (HB) and to assess the correlation between stress-induced changes in SD and HB and other functional parameters. We prospectively studied 32 control subjects (Group-1) and 60 ischemic patients (Group-2). Stress-induced changes were calculated as stress minus rest (Δ). LVMD was defined as post-stress increases of either SD or HB. Group-2 showed higher ΔSD and ΔHB in early than in delayed images: early ΔSD: 1.63 (− 0.37 to 4.83) vs. delayed ΔSD: − 0.39 (− 3.82 to 1.74); early ΔHB: 2.50 (− 4 to 12) vs. ΔHB delayed: − 4 (− 15.75 to 4), all p
Databáze: OpenAIRE
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