Blood pressure in children with renal cysts and diabetes syndrome
| Autor: | Filip Fencl, Ulrike John-Kroegel, Veit Grote, Tomáš Seeman, Richard Klaus, Bärbel Lange-Sperandio, Kveta Blahova, Stepanka Pruhova, Katharina Hermes, Friederike Weigel |
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| Rok vydání: | 2021 |
| Předmět: |
Cystic kidney
medicine.medical_specialty Ambulatory blood pressure Proteinuria business.industry Renal function medicine.disease 03 medical and health sciences 0302 clinical medicine Blood pressure 030225 pediatrics Internal medicine Diabetes mellitus Pediatrics Perinatology and Child Health Polycystic kidney disease Albuminuria Medicine 030212 general & internal medicine medicine.symptom business |
| Zdroj: | European Journal of Pediatrics. 180:3599-3603 |
| ISSN: | 1432-1076 0340-6199 |
| DOI: | 10.1007/s00431-021-04165-1 |
| Popis: | Cystic kidney diseases such as autosomal recessive or dominant polycystic kidney disease (ARPKD and ADPKD) are associated with high prevalence of arterial hypertension. On the contrary, studies on hypertension in children with renal cysts and diabetes (RCAD) syndrome caused by abnormalities in the HNF1B gene are rare. Therefore, the primary aim of our study was to investigate the prevalence of high blood pressure in children with RCAD syndrome due to HNF1B gene abnormalities and secondary to search for possible risk factors for development of high blood pressure. Data on all children with genetically proven RCAD syndrome from three pediatric nephrology tertiary centers were retrospectively reviewed (office blood pressure (BP), ambulatory blood pressure monitoring (ABPM), creatinine clearance, renal ultrasound, echocardiography, albuminuria/proteinuria). High blood pressure was defined as BP ≥ 95th percentile of the current ESH 2016 guidelines and/or by the use of antihypertensive drugs. Thirty-two children with RCAD syndrome were investigated. Three children received ACE inhibitors for hypertension and/or proteinuria. High blood pressure was diagnosed using office BP in 22% of the children (n = 7). In the 7 performed ABPM, 1 child (14%) was diagnosed with hypertension and one child with white-coat hypertension. Creatinine clearance, proteinuria, albuminuria, body mass index, enlargement, or hypodysplasia of the kidneys and prevalence of HNF1B-gene deletion or mutation were not significantly different between hypertensive and normotensive children. Conclusion: High blood pressure is present in 22% of children with RCAD syndrome. |
| Databáze: | OpenAIRE |
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