Activity of some enzymes of energy metabolism in the myocardium and liver after large doses of noradrenalin
| Autor: | N. A. Novikova, K. I. Shanygina |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system Hexokinase biology Glucokinase medicine.medical_treatment Intraperitoneal injection Dehydrogenase General Medicine General Biochemistry Genetics and Molecular Biology Enzyme assay chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Lactate dehydrogenase Internal medicine medicine biology.protein Catecholamine medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 80:1425-1427 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00842627 |
| Popis: | Increases are found in the lactate concentration and lactate dehydrogenase activity in the myocardium and hexokinase and glucose-6-phosphate dehydrogenase activity in the myocardium and liver 24 h after intraperitoneal injection of large doses of noradrenalin, after exhaustion of its reserves in the myocardial and hepatic tissues of rats. Activity of glucokinase, which phosphorylates glucose when present in high concentrations in the medium, is reduced. Changes in enzyme activity thus observed are similar to those developing in degeneration of denervated tissues, with a sharply reduced catecholamine content, and they confirm the important role of the sympathetic nervous system and its mediators in the mechanism for controlling enzymic processes of energy metabolism in the myocardium and liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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