Association between polymorphisms of DNA repair genes and risk of type 2 diabetes mellitus in the Turkish population
| Autor: | Nihal Yigitbasi, Zeynep Karaali, Leman Melis Yurdum, Şakir Zeybek, Hayriye Arzu Ergen, Umit Yilmaz, Neslihan Tokmak, Nesibe Yilmaz |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Turkish population business.industry DNA repair Biochemistry (medical) Clinical Biochemistry Type 2 Diabetes Mellitus Bioinformatics Biochemistry 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Medicine business Molecular Biology |
| Zdroj: | Turkish Journal of Biochemistry. 43:167-172 |
| ISSN: | 1303-829X |
| Popis: | Objectives: DNA repair mechanisms work insufficiently in T2DM patients and hyperglycemia seen in diabetes disturbs the oxidant-antioxidant balance thus cause oxidative damage on DNA. The effects of the DNA repair genes’ have not yet been investigated on diabetes. The aim of this study was to investigate the association between APE1 Asp148Glu and XPG Asp1104His polymorphisms with T2DM in the Turkish population. Material and methods: Sixty-five T2DM patients and 54 healthy individuals were included to this study as control. The polymerase chain reaction-restriction fragment length polymorphism techniques were used. Results: When the study groups were compared, serum HDL-cholesterol levels were found statistically elevated in the controls. Once the APE1 Asp148Glu polymorphism distribution between the patient and control groups was investigated, the Glu/Glu genotype ratio was found significantly higher in the control group. Furthermore, the Asp/Glu genotype and the Asp allele prevalences were observed to be higher in the patient group. Also, patients with the Asp/Asp genotype had higher serum HDL-cholesterol levels than the others. Conclusion: Despite the small number of subjects included, it could be interpreted that the Glu allele of the APE1 Asp148Glu polymorphism might be protective against and the Asp allele may be contributing to the development of diabetes. |
| Databáze: | OpenAIRE |
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