Effects of Aspirin on the Development of Helicobacter pylori-Induced Gastric Inflammation and Heterotopic Proliferative Glands in Mongolian Gerbils
| Autor: | Qing Gu, Ying Jie Liang, Guo Qing Li, Chi Hin Cho, Harry Hua-Xiang Xia, Masae Tatematsu, Benjamin C.Y. Wong, Han-liang Lin, Min Hu Chen, Man-Fung Yuen, Tetsuya Tsukamoto, Liang Qiao, Annie On-On Chan, Pin Jin Hu, Wallace H.L. So |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Aspirin Pathology biology business.industry Gastroenterology Inflammation General Medicine Helicobacter pylori Hyperplasia bacterial infections and mycoses biology.organism_classification medicine.disease Epithelium Infectious Diseases medicine.anatomical_structure Apoptosis Internal medicine Medicine Prostaglandin E2 Gastritis medicine.symptom business medicine.drug |
| Zdroj: | Helicobacter. 13:20-29 |
| ISSN: | 1083-4389 |
| DOI: | 10.1111/j.1523-5378.2008.00585.x |
| Popis: | Background: Helicobacter pylori infection is a major cause of gastritis and gastric carcinoma. Aspirin has anti-inflammatory and antineoplastic activity. The aim of the present study was to determine the effects of aspirin on H. pylori-induced gastritis and the development of heterotopic proliferative glands. Methods: H. pylori strain SS1 was inoculated into the stomachs of Mongolian gerbils. Two weeks after inoculation, the animals were fed with the powder diets containing 0 p.p.m. (n = 10), 150 p.p.m. (n = 10), or 500 p.p.m. (n = 10) aspirin. Mongolian gerbils were killed after 36 weeks of infection. Uninfected Mongolian gerbils (n = 10) were used as controls. Histologic changes, epithelial cell proliferation and apoptosis, and prostaglandin E2 (PGE2) levels of gastric tissue were determined. Results: H. pylori infection induced gastric inflammation. Administration of aspirin did not change H. pylori-induced gastritis, but alleviated H. pylori-induced hyperplasia and the development of heterotopic proliferative glands. Administration of aspirin accelerated H. pylori-associated apoptosis but decreased H. pylori-associated cell proliferation. In addition, the increased gastric PGE2 levels due to H. pylori infection were suppressed by treatment with aspirin, especially at the dose of 500 p.p.m. Conclusions: Aspirin alleviates H. pylori-induced hyperplasia and the development of heterotopic proliferative glands. Moreover, aspirin increases H. pylori-induced apoptosis. We demonstrated the antineoplastic activities of aspirin in H. pylori-related gastric carcinogenesis. |
| Databáze: | OpenAIRE |
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