Synthesis, structural characterization and biological properties of cyclometalated iridium(III) complexes containing 2-methyl-3-{(E)-[(quinolin-2-yl)methylidene]amino}quinazolin-4(3H)-one

Autor: Kishore Bhat, Ramesh S. Vadavi, Vijay Kumbar, Satish S. Bhat, Rahul V. Pinjari, Ray J. Butcher, N.K. Lokhanath, Vidyanand K. Revankar, Kalagouda B. Gudasi, S. Naveen
Rok vydání: 2022
Předmět:
Zdroj: Inorganica Chimica Acta. 531:120735
ISSN: 0020-1693
Popis: Two Iridium(III) complexes [Ir(ppy)2((mqmaq)]+ (1) and [Ir(bhq)2((mqmaq)]+ (2) {ppy=2-phenylpyridine, bhq= benzo[h]quinoline, mqmaq=2-methyl-3-{(E)-[(quinolin-2-yl)methylidene]amino}quinazolin-4(3H)-one} have been designed, synthesized and structurally characterized. Complex 2 has been structurally characterized by single-crystal X-ray structure determination. The experimentally obtained results of photophysical properties of complexes 1 and 2 well agree with the theoretically calculated results acquired by density functional theory (DFT) studies. The HOMO of complexes 1 and 2 are delimited on the iridium and cyclometalated aromatic ligands, while LUMO, is localized on quinoline-based mqmaq ligand whereas LUMO+1, and LUMO+2 are primarily restricted on cyclometalated ligands. The interaction of complexes with calf thymus DNA (CT-DNA) was investigated by absorption titration and emission titration experiments. Furthermore, the cytotoxicity and cellular localization properties of these complexes towards HeLa cells have been investigated.
Databáze: OpenAIRE