Mechanism of interaction of certain flavonoids with phosphatidylcholine of cellular membranes

Autor:	R. S. Nasibullin, E. R. Fakhretdinova, Yu. G. Afanas’eva, Leonid V. Spirikhin
Rok vydání:	2007
Předmět:	Pharmacology chemistry.chemical_compound Membrane chemistry Stereochemistry Chemical shift Phosphatidylcholine Drug Discovery Phospholipid Choline Myricetin Ring (chemistry) Kaempferol
Zdroj:	Pharmaceutical Chemistry Journal. 41
ISSN:	1573-9031 0091-150X
Popis:	Complex formation of cellular phospholipid with 3,5,7,4′-tetrahydroxyflavonol (kaempferol); 3,5,7,3′,4′-pentahydroxyflavonol ′quercetin); and 3,5,7,3′,4′,5′-hexahydroxyflavonol (myricetin) was studied using quantum chemistry and 13C NMR spectroscopy. It was shown that complexes form through π-electron systems. Chemical shifts of 13C nuclei in various rings of the flavonoids and the choline of phosphatidylcholine that were generated through complex formation were determined. It was established that the most probable complex was that where ring C interacts with choline; ring A, simultaneously with the phosphate of phosphatidylcholine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::67df360e11261eb9ff8669c7adee50a6 https://doi.org/10.1007/s11094-007-0080-8 Zobrazit plný text záznamu Full text from SpringerLink