| Popis: |
Purpose: To study the concentrations of trace metals and nonmetals el ements in different types of gallstones (cholesterol-, pigment-, mixed- and calcium carbonate type) and to explore the formation mechanisms of gallstones. Method: Inductively coupled plasma emission spectrometer (ICP-AES) was used to determine the concentrations of calcium, manganese, magnesium, iron, copper, zinc, sulfur, and phosphorus. Results: Calcium, copper, sulfur and phosphorus play important roles in the formation of pigment stones. High concentrations of Cu 2+ and Ca 2+ ions can coordinate with bilirubin to form calcium bilirubinate and copper bilirubinate, respectively; phosphorus and sulfur suggest the presence of proteins in gallstones, and some proteins (such as mucin) can promote the formation of gallstones. Conclusions: The contents of metal and nonmetal elements in gallstones can accurately be detected using ICP-AES. The formation of different types of gallstones is closely related to the difference of these elements. This study is of great significance to reveal the cause of gallstones formation. |
