New cucurbitane type triterpenes from Momordica foetida Schumach. (Cucurbitaceae)

Autor:	Ayaz Ahmed, Ernestine Nkwengoua Tchouboun, Muhammad Ali, Désiré Soh, Rémy Bertrand Teponno, Barthelemy Nyasse, Lazare Sidjui Sidjui, Ulrich Dzo Defokou, Bruno Tchebemou Bakang, Mehreen Lateef, Yves Oscar Ditchou Nganso
Rok vydání:	2020
Předmět:	chemistry.chemical_classification biology Traditional medicine DPPH Momordin Momordica foetida Plant Science Cucurbitane biology.organism_classification Biochemistry Terpene chemistry.chemical_compound Enzyme chemistry Phytochemical Agronomy and Crop Science Cucurbitaceae Biotechnology
Zdroj:	Phytochemistry Letters. 38:90-95
ISSN:	1874-3900
DOI:	10.1016/j.phytol.2020.05.010
Popis:	Phytochemical studies on Momordica foetida led to the isolation and characterization of Momordin (23,24,25,26,27-pentanorcucurbitacin) (3), a new pentanor cucurbitane along with the known β-sitosterol 3-O-β-D-glucopyranoside (4), β-sitosterol (5) and kaempferol-7-O-s-D-glucopyranoside (6). In adition to those components, two previously unreported cucurbitane glucosides, namely 3β-hydroxy-7-oxo-23(R)-cucurbita-5,24-diene-23-O-β-D-glucopyranoside (Momordiside A) (1) and 3β-hydroxy-7β-methoxy-23(R)-cucurbita-5,24-diene-23-O-β-D-glucopyranoside (Momordiside B) (2) were also obtained. The structures were elucidated by HR-ESI-MS and spectroscopic analysis including 1D- and 2D-NMR. Compounds 1 and 2 showed significant antioxidant potential in DPPH radical scavenging assay. In addition, compound 2 further revealed significant inhibitory potential against the enzyme urease in vitro as well as moderate activity against oral cancer cell line CAL-27.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::67da8df5d545e014ff80912e03c6acf9 https://doi.org/10.1016/j.phytol.2020.05.010 Zobrazit plný text záznamu Full Text from ScienceDirect