| Autor: |
Jorge Acevedo, Josefina Romaguera, David Sidransky, Adriana Baez, José F. Rodríguez-Orengo, Keilyn Vale, Luigi Marchionni, Amanda Garcia Negron, Claudio Zanettini, Una Pipic, Ana Purcell-Wiltz, Denise Ortiz, Fernando T. Zamuner, Lorena De Jesus, Vanessa Rivera Amill, Ivonne Jimenez, Rafael Guerrero-Preston, Nike Beaubier, Christopher E. Mason, Matthew MacKay, Gaurav Khullar, Liliana Viera, Karem Caraballo, Alberto Ortiz, Gabriela T. Pérez, Yaima Miranda, Andrea Arias Garcia, Jessica Metti, Rachet Baits, Raphael Sanchez Torres |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Several genomic epidemiology tools have been developed to track the public and population health impact of SARS-CoV-2 community spread worldwide. A SARS-CoV-2 Variant of Concern (VOC) B.1.1.7, known as 501Y.V1, which shows increased transmissibility, has rapidly become the dominant VOC in the United States (US). Our objective was to develop an evidenced-based genomic surveillance algorithm that combines RT-PCR and sequencing technologies to identify VOCs. Deidentified data were obtained from 508,969 patients tested for COVID-19 with the TaqPath COVID-19 RT-PCR Combo Kit (ThermoFisher) in four CLIA certified clinical laboratories in Puerto Rico (n=86,639) and in three CLIA certified clinical laboratories in the US (n=422,330). TaqPath data revealed a frequency of S Gene Target Failure (SGTF) >47% for the last week of March 2021, in both Puerto Rico and US laboratories. The monthly frequency of SGTF in Puerto Rico steadily increased exponentially from 4% in November 2020 to 47% in March 2021.The weekly SGTF rate in US samples was high (>8%) from late December to early January, and then also increased exponentially through April (48%). The exponential increase in SGFT prevalence in Puerto Rico is concurrent with a sharp increase in VOCs among all SARS-CoV-2 sequences from Puerto Rico uploaded to GISAID (n=461). B.1.1.7 frequency increased from |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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