Rapid, nongenomic signaling effects of several xenoestrogens involved in early- vs. late-stage prostate cancer cell proliferation
| Autor: | Cheryl S. Watson, Luke Y. Koong |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
endocrine system
medicine.medical_specialty Membrane estrogen receptor Diethylstilbestrol food and beverages Genistein Estrogen receptor General Medicine Resveratrol Coumestrol medicine.disease chemistry.chemical_compound Prostate cancer Endocrinology chemistry Internal medicine medicine Phytoestrogens hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Endocrine Disruptors. 3:e995003 |
| ISSN: | 2327-3747 |
| DOI: | 10.4161/23273747.2014.995003 |
| Popis: | Xenoestrogens (XEs) are exogenous mimics capable of binding to estrogen receptors (ERs), competing with/disrupting the actions of physiological estrogens, and promoting tumor growth in the prostate and other endocrine tissues. Humans are exposed to numerous XEs including environmental contaminants such as plastics monomer bisphenol A (BPA), and dietary phytoestrogens such as coumestrol and genistein from soy, and resveratrol, highest in red grapes. There is growing interest in the ability of phytoestrogens to prevent or treat tumors. We previously reported that multiple cellular mechanisms influence the number of prostate cancer cells after estradiol or diethylstilbestrol treatment. We now examine the effect of these XEs on signaling mechanisms that alter the number of LAPC-4 (androgen-dependent) and PC-3 (androgen-independent) cells at environment- and diet-relevant concentrations. Coumestrol and genistein both increased the number of LAPC-4 and PC-3 cells dramatically. Rapid alterations of phospho- and ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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