Efforts in diagnosing early leprosy using serological techniques
| Autor: | B. K. Girdhar, Utpal Sengupta, Kiran Katoch, Om Parkash, M. K. Beuria |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
biology
business.industry medicine.drug_class General Medicine Monoclonal antibody medicine.disease General Biochemistry Genetics and Molecular Biology In vitro Serology Antibody response Antigen Immunology biology.protein Full thickness skin Medicine Leprosy Antibody General Agricultural and Biological Sciences business |
| Zdroj: | Journal of Biosciences. 22:111-116 |
| ISSN: | 0973-7138 0250-5991 |
| DOI: | 10.1007/bf02703623 |
| Popis: | Skin scrapings obtained from the lesions of leprosy patients of all types showed 96 % positivity to the serum antibody competition test using monoclonal antibody (ML04)to 35 kDa antigen ofMycobacterium leprae. Further, in vitro culture of full thickness skin biopsies from lepromatous patients were noted to release IgG antibodies toM. leprae with a peak antibody response at 48 h. The significance of this local antibody response toM. leprae in skin has been discussed for its possible use in diagnosing early leprosy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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