The Correlation BetweenIn VitroAntioxidant Activity and Immunomodulatory Activity of Enzymatic Hydrolysates from Selenium-Enriched Rice Protein
| Autor: | Xi Chen, Yong Fang, Kunlun Liu, Luo Peizhu, Mengjia Du, Fei Pei, Qiuhui Hu, Qiu Weifen, Benard Muinde Kimatu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification 030109 nutrition & dietetics Antioxidant Phagocytosis medicine.medical_treatment chemistry.chemical_element 04 agricultural and veterinary sciences Trypsin 040401 food science Hydrolysate 03 medical and health sciences 0404 agricultural biotechnology Enzyme chemistry Biochemistry Rice protein medicine Macrophage proliferation Selenium Food Science medicine.drug |
| Zdroj: | Journal of Food Science. 82:517-522 |
| ISSN: | 0022-1147 |
| Popis: | The antioxidant and immunomodulatory activities of selenium-enriched rice protein hydrolysates (Se-PH) were evaluated by a cellular antioxidant activity test and macrophage proliferation and phagocytosis assays, respectively. The results showed that trypsin hydrolysate provided the highest proliferation rate of 60.91% at a concentration of 100 μg/mL. Moreover, a remarkable rise in the phagocytosis rates for trypsin hydrolysate (64.1%) and pepsin-trypsin hydrolysate (54.5%) was observed when the sample concentrations were increased to 50 μg/mL. A positive correlation was found between the phagocytic ability of macrophages and both the selenium concentration and the degree of hydrolysis of Se-PH, and the correlation coefficients R obtained were 0.792 and 0.930 (P < 0.05), respectively. The capacity of Se-PH to inhibit the oxidation of dichlorodihydrofluorescein had a significant negative correlation with the phagocytic ability of macrophages (R = -0.840, P < 0.05). In conclusion, a positive correlation was found between the antioxidant activity and the immunomodulatory activity of Se-PH, which could be used as potential functional food additives for improving human health. |
| Databáze: | OpenAIRE |
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