GSH-resistant and highly cytoselective ruthenium(ii )-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents
| Autor: | Sourav De, S. K. Ashok Kumar, Ajay Sharma S, Utpal Das, Nilmadhab Roy, Priyankar Paira, Sudhindra Pete, Binoy Kar, Debashis Panda |
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| Rok vydání: | 2021 |
| Předmět: |
p-Cymene
biology 010405 organic chemistry Cancer chemistry.chemical_element Glutathione 010402 general chemistry medicine.disease biology.organism_classification 01 natural sciences Combinatorial chemistry 0104 chemical sciences Ruthenium Inorganic Chemistry HeLa chemistry.chemical_compound chemistry medicine Phenol Platinum |
| Zdroj: | Dalton Transactions. 50:10369-10373 |
| ISSN: | 1477-9234 1477-9226 |
| DOI: | 10.1039/d1dt01604k |
| Popis: | To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(II)-arene complexes. In this regard, luminescent ruthenium(II)-p-cymene-imidazophenanthroline complexes were developed as promising highly cytoselective cancer theraputic agents for HeLa and Caco-2 cells. |
| Databáze: | OpenAIRE |
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