RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
| Autor: | L. Zhen, Luana Schito, Preethi Korangath, Carmen Chak-Lui Wong, Jasper Chen, W. A. Mitzner, Pallavi Chaturvedi, Gregg L. Semenza, Paul T. Winnard, Hong Wei, Daniele M. Gilkes, Saraswati Sukumar, Venu Raman, Balaji Krishnamachary, Huafeng Zhang |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
animal structures endocrine system diseases L1 Biology Metastasis Angiopoietin 03 medical and health sciences 0302 clinical medicine ANGPTL4 RNA interference Genetics medicine skin and connective tissue diseases Molecular Biology 030304 developmental biology 0303 health sciences medicine.disease Primary tumor female genital diseases and pregnancy complications 3. Good health medicine.anatomical_structure Apoptosis 030220 oncology & carcinogenesis Immunology Cancer research Blood vessel |
| Zdroj: | Oncogene. 31:1757-1770 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/onc.2011.365 |
| Popis: | Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In this study we demonstrate that inhibition of hypoxia-inducible factor (HIF) activity in BrCa cells by RNA interference or digoxin treatment inhibits primary tumor growth and also inhibits the metastasis of BrCa cells to the lungs by blocking the expression of angiopoietin-like 4 (ANGPTL4) and L1 cell adhesion molecule (L1CAM). ANGPTL4 is a secreted factor that inhibits EC-EC interaction, whereas L1CAM increases the adherence of BrCa cells to ECs. Interference with HIF, ANGPTL4 or L1CAM expression inhibits vascular metastasis of BrCa cells to the lungs. |
| Databáze: | OpenAIRE |
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