Survival after severe methemoglobinemia secondary to sodium nitrate ingestion
| Autor: | David Vearrier, Maricel Dela Cruz, Joshua Glick, Seth H. Merker |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Preservative
medicine.diagnostic_test business.industry 030208 emergency & critical care medicine Methemoglobinemia medicine.disease Methemoglobin 03 medical and health sciences chemistry.chemical_compound Pulse oximetry 0302 clinical medicine Nitrate chemistry Sodium nitrate Anesthesia medicine Ingestion business 030217 neurology & neurosurgery Oxygen saturation (medicine) |
| Zdroj: | Toxicology Communications. 2:21-23 |
| ISSN: | 2473-4306 |
| Popis: | Sodium nitrate is used as a food preservative and color fixative. Sodium nitrate poisoning has occurred in the setting of well water contamination with nitrogenous waste runoff. Most clinically significant exposures result from improper labeling or unintentional use. We describe a case of severe methemoglobinemia associated with intentional sodium nitrate ingestion. A 23-year-old female presented to the emergency department (ED) for an intentional ingestion of sodium nitrate obtained from an online distributor. On arrival, blood pressure was 89/42 mmHg and oxygen saturation was 74% on pulse oximetry. Due to clinical decline, the patient underwent endotracheal intubation in the ED. Co-oximetry demonstrated a methemoglobin (MetHb) level of 92.7%, which is among the highest recorded MetHb levels. The patient received two doses of 1 mg/kg methylene blue and experienced dramatic clinical improvement and subsequent successful extubation. Healthy erythrocytes undergo oxidative stress from normal metaboli... |
| Databáze: | OpenAIRE |
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