A study of ad-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9

Autor:	Chiara Calugi, Antonio Guarna, Andrea Trabocchi, Francesca Bianchini, Jessica Ruzzolini, Gloria Menchi, Lido Calorini
Rok vydání:	2015
Předmět:	Pharmacology Angiogenesis Peptidomimetic Melanoma Organic Chemistry Pharmaceutical Science Biology Matrix metalloproteinase medicine.disease Biochemistry Molecular biology Endothelial stem cell In vivo Drug Discovery medicine Molecular Medicine Zymography Proline
Zdroj:	MedChemComm. 6:277-282
ISSN:	2040-2511 2040-2503
Popis:	A D-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting the invasion inhibitory activity and capacity of blocking capillary network formation in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::67becb72ca95d6d9ae68b4754ab00f9e https://doi.org/10.1039/c4md00287c Zobrazit plný text záznamu