A study of ad -proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9
Autor: | Chiara Calugi, Antonio Guarna, Andrea Trabocchi, Francesca Bianchini, Jessica Ruzzolini, Gloria Menchi, Lido Calorini |
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Rok vydání: | 2015 |
Předmět: | |
Zdroj: | MedChemComm. 6:277-282 |
ISSN: | 2040-2511 2040-2503 |
Popis: | A D-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting the invasion inhibitory activity and capacity of blocking capillary network formation in vivo. |
Databáze: | OpenAIRE |
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