Fluoroquinolones Metal Complexes as Potent Antibacterial Agents

Autor:	Savita Khatri, Manoj Kumar, Harkesh Sehrawat, S.P. Khatkar, V.B. Taxak, Rajesh Kumar
Rok vydání:	2022
Předmět:	heterocyclic compounds General Chemistry biochemical phenomena metabolism and nutrition bacterial infections and mycoses
Zdroj:	Asian Journal of Chemistry. 34:1055-1065
ISSN:	0975-427X 0970-7077
DOI:	10.14233/ajchem.2022.23600
Popis:	In this review article, a brief discussion of fluoroquinolones (FQs) and their tendency to form metal complexes is presented. The effect of FQs-M complexes on disease causing microorganisms is also summarized. The antibacterial activity of various metal complexes of various fluoroquinolones [norfloxacin (NOR), ciprofloxacin (CIP), levofloxacin (LEVO), ofloxacin (OFL), gemifloxacin (GEMI), gatifloxacin (GATI), moxifloxacin (MOX), enrofloxacin (ENRO), sparfloxacin (SPRX)] is reviewed by comparing zone of inhibition and MIC values of metal complexes. It is found to be either corresponding with the parent fluoroquinolone or in some cases their respective metal complexes exhibit stronger antibacterial activity. New approach towards synthesis of FQ-metal complexes has led to formation of compounds with the anticancer and antiviral activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::67ace996febeefde4c647246612a5f31 https://doi.org/10.14233/ajchem.2022.23600 Zobrazit plný text záznamu