Structure and Immunomodulatory Activity of Glycogen Derived from Honeybee Larvae (Apis mellifera)
| Autor: | Yuto Nagasaki, Shoichi Onishi, Yusuke Okamoto, Kyohei Higashi, Misato Abe, Toshihiko Toida |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology Glycan animal structures Glycogen biology Chemistry fungi Pharmaceutical Science Interleukin Biological activity General Medicine Hot water extraction 03 medical and health sciences chemistry.chemical_compound Ingredient 030104 developmental biology 0302 clinical medicine Biochemistry Functional food 030220 oncology & carcinogenesis parasitic diseases biology.protein Tumor necrosis factor alpha |
| Zdroj: | Biological and Pharmaceutical Bulletin. 44:1156-1159 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.b21-00239 |
| Popis: | Honeybee larvae have been recognized as nutrient-rich food in many countries. Although glycogen, a storage form of glucose in animals, is synthesized in honeybee larvae, there is no information on the structure of glycan and its biological activity. In this study, we successfully extracted glycogen from honeybee larvae using hot water extraction and investigated the structure and biological activity of glycan. It was found that the molecular weight of glycogen from honeybee larvae is higher than that of glycogen from bovine liver and oysters. In addition, treatment of RAW264.7 cells with glycogen from honeybee larvae resulted in a much higher production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 than treatment with glycogen from either bovine liver or oysters. These results suggest that the high molecular weight glycogen from honeybee larvae is a functional food ingredient with immunomodulatory activity. |
| Databáze: | OpenAIRE |
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