Transition metal-catalyzed C H functionalization of arylacetic acids for the synthesis of benzothiadiazine 1,1-dioxides
| Autor: | B. Pownthurai, Atul C. Chaskar, V. Mohanasrinivasan, Bhausaheb N. Patil, Kamlesh S. Vadagaonkar, Jatin J. Lade, Aniket S. Karpe |
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| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Condensation Substrate (chemistry) 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Transition metal Benzothiadiazine Drug Discovery Functional group Surface modification |
| Zdroj: | Tetrahedron Letters. 60:891-894 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2019.02.031 |
| Popis: | Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides has been developed. The method involves C H functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonamide. This functional group tolerant approach furnished benzothiadiazine 1,1-dioxide derivatives in good to excellent yields. Broad substrate scope, inexpensive catalyst and high product yields are notable features of this protocol. |
| Databáze: | OpenAIRE |
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