ChemInform Abstract: Thienopyridines: Nitric Oxide Synthase Inhibitors with Potent in vivo Activity

Autor:	Anant M. Ghelani, Alan V. Wallace, Nigel Boughton-Smith, Peter Hamley, Tinker Alan, Haydn Beaton, David J. Nicholls
Rok vydání:	2010
Předmět:	Nitric Oxide Synthase Inhibitors Biochemistry Chemistry In vivo Thienopyridines Potency General Medicine Selectivity Neuronal Nitric Oxide Synthase
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
Popis:	5-Substituted 7-amino-4,5-tetrahydrothieno[2,3-c]pyridines and 6-substituted 4-amino-6,7-dihydrothieno[3,2-c]pyridines were shown to be exceptionally potent inhibitors of inducible and neuronal nitric oxide synthase. Selectivity and potency could be modulated by variation of the 5- or 6-substituent. Compound 3e showed potent in vivo inhibition of iNOS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::679edcf99439d10a1b14d445a5c7f14b https://doi.org/10.1002/chin.200132150 Zobrazit plný text záznamu Plný text