Effect of antimicrobials on Stenotrophomonas maltophilia biofilm

Autor:	Bárbara Ellen Santos Carvalhais, Kênia Valéria dos Santos, Cristiana de Souza E Silva
Rok vydání:	2021
Předmět:	Microbiology (medical) biology Chemistry Chloramphenicol Biofilm Ceftazidime biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial biology.organism_classification Microbiology Stenotrophomonas maltophilia Levofloxacin medicine Gentamicin medicine.drug
Zdroj:	Future Microbiology. 16:83-93
ISSN:	1746-0921 1746-0913
DOI:	10.2217/fmb-2020-0115
Popis:	Aim: To evaluate the activity of five antimicrobials against young and mature Stenotrophomonas maltophilia biofilms. Materials & methods: Nineteen clinical strains from hemoculture of hemodialysis patients were tested for biofilm kinetics, MIC and minimum biofilm inhibitory concentration (MBIC) in young and mature biofilms. Results: All strains were moderate biofilm producers. MIC showed total susceptibility to levofloxacin and trimethoprim-sulfamethoxazole and partial resistance to ceftazidime (63.2%) and gentamicin (21%). Young and mature biofilms showed the lowest MBIC/MIC ratio for gentamicin, chloramphenicol and levofloxacin, respectively. The highest MBIC/MIC was for trimethoprim-sulfamethoxazole (young) and ceftazidime (mature). Conclusion: Gentamicin displayed surprising activity against S. maltophilia biofilms. Chloramphenicol was indicated as a good option against young S. maltophilia biofilms, and trimethoprim-sulfamethoxazole showed limited antibiofilm activity.
Databáze:	OpenAIRE
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