Thyrocalcitonin III. Die Synthese des α-Thyrocalcitonins: Vorläufige Mitteilung
| Autor: | P. Sieber, M. Brugger, Werner Rittel, B. Riniker, B. Kamber |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Organic Chemistry Peptide Sulfoxide Biological activity Trypsin Biochemistry Catalysis Thin-layer chromatography Inorganic Chemistry chemistry.chemical_compound Electrophoresis chemistry Drug Discovery medicine Physical and Theoretical Chemistry Hydrogen peroxide Peptide sequence medicine.drug |
| Zdroj: | Helvetica Chimica Acta. 51:924-928 |
| ISSN: | 0018-019X |
| DOI: | 10.1002/hlca.660510431 |
| Popis: | A synthesis of the dotriacontapeptide sequence I, reported by Neher et al. [1] for porcine α-thyrocalcitonin (α-TC), is described. The synthetic peptide is shown to be identical with α-TC by thin layer chromatography and electrophoresis, by the pattern of trypsin degradation, and by its biological activity. Oxidation with hydrogen peroxide gave the methionine25 sulfoxide derivative, which was identical with α-TC-sulfoxide (formerly called β-thyrocalcitonin) from pig thyroids. |
| Databáze: | OpenAIRE |
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