Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after 3-day dry immersion

Autor:	Daniil V. Popov, Pavel A. Makhnovskii, Viktor G. Zgoda, Guzel R. Gazizova, Tatiana F. Vepkhvadze, Egor M. Lednev, Evgeniia S. Motanova, Evgeny A. Lysenko, Oleg I. Orlov, Elena S. Tomilovskaya
Rok vydání:	2023
Předmět:	Physiology Physiology (medical)
Zdroj:	Journal of Applied Physiology. 134:1256-1264
ISSN:	1522-1601 8750-7587
Popis:	Three-day dry immersion (a model of physical unloading) substantially changes the transcriptomic profile in the human soleus muscle, a muscle with predominantly slow-twitch fibers and strong postural function; despite this, we found no effect on the muscle proteome (highly abundant proteins). Dry immersion markedly reduces ADP-stimulated respiration; this decline is not accompanied by a decrease in the content of mitochondrial proteins/respiratory enzymes, indicating the disruption in regulation of cellular respiration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::678ffef9570ccf13c96fdc6cf6690621 https://doi.org/10.1152/japplphysiol.00048.2023 Zobrazit plný text záznamu