Reaction of 3-Amino-4,6-diarylthieno[2,3-b]pyridine-2-carboxamides with Ninhydrin

Autor:	Inna V. Aksenova, Vladimir Strelkov, Gennady D. Krapivin, Nicolai A. Aksenov, Vyacheslav Muraviev, Victor V. Dotsenko, D. Yu. Lukina, L. V. Dyadyuchenko
Rok vydání:	2020
Předmět:	Pyrimidine 010405 organic chemistry medicine.medical_treatment Sulfuric acid General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Bioavailability Catalysis chemistry.chemical_compound chemistry Ninhydrin Pyridine medicine Antidote Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Russian Journal of General Chemistry. 90:948-960
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363220060043
Popis:	The reaction of N-substituted amides of 3-amino-4,6-diarylthieno[2,3-b]pyridine-2-carboxylic acids with ninhydrin in the presence of catalytic amounts of sulfuric acid gave 1′-spiro[indene-2,2′-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine]-1,3,4′(3′H)-triones. Structure of a number of key compounds was studied using 2D NMR spectroscopy; the bioavailability parameters of the obtained compounds in silico were calculated. In a laboratory experiment, a moderate antidote effect was revealed with respect to the 2,4-D herbicide for one compound.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::678d08261e8af0f7f9d83d82fa9e4dec https://doi.org/10.1134/s1070363220060043 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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