Gabapentin in der Behandlung der akuten Manie

Autor:	Claus Normann, Heinz Grunze, J. Walden, Benedikt L. Amann, Andreas Erfurth
Rok vydání:	1999
Předmět:	Gabapentin Lithium (medication) business.industry Perazine behavioral disciplines and activities Clinical trial Psychiatry and Mental health Mood Neurology Anesthesia mental disorders medicine Potency In patient Neurology (clinical) medicine.symptom business Mania medicine.drug
Zdroj:	Fortschritte der Neurologie · Psychiatrie. 67:256-260
ISSN:	1439-3522 0720-4299
Popis:	We present the case of a 60-year old bipolar-I-patient showing a rapid antimanic response to gabapentin after having been non-responsive to lithium and perazine. This case encouraged us to further evaluate the antimanic potency of gabapentin in an open label trial. 20 patients with acute mania were treated for up to 21 days with gabapentin in a dose range from 1200 to 4800 mg/day. Ten patients were treated with gabapentin as add-on medication and ten patients were treated with a high dose of gabapentin alone. The BRMAS score declined significantly in patients with moderate mania, whereas gabapentin alone was not efficacious in patients with very severe mania. Keeping in mind the limitations of an open study, it can still be said that gabapentin as add-on medication with other effective mood stabilizers appears to be safe and efficacious in the treatment of moderate mania.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::678a4cf4967bf78bd7b7e2b6357c17e6 https://doi.org/10.1055/s-2007-994974 Zobrazit plný text záznamu