Dried blood spot thyroglobulin as a biomarker of iodine status in pregnant women
| Autor: | Stinca, Sara, Andersson, Maria, Weibel, Sandra, Herter-Aeberli, Isabelle, Fingerhut, Ralph, Gowachirapant, Sueppong, Hess, Sonja Y., Jaiswal, Nidhi, Jukić, Tomislav, Kusić, Zvonko, Mabapa, Ngoako Solomon, Nepal, Ashwini K., San Luis, Teofilo O. L., Qing-Zhen, Jia, Zimmermann, Michael B. |
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| Jazyk: | angličtina |
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| ISSN: | 0021-972X 1945-7197 |
| Popis: | Context: Thyroglobulin (Tg) could be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies. Objectives: Our aims were to (1) establish and test a reference range for DBS-Tg in PW; (2) determine whether co-measurement of Tg antibodies (Abs) is necessary to define population iodine status. Design, Setting, and Participants: Standardized cross-sectional studies of 3870 PW from 11 countries. For the DBS-Tg reference range, we included TgAb-negative PW (n = 599) from 3 countries with sufficient iodine intake. Main Outcome Measures: We measured the urinary iodine concentration and DBS thyroid-stimulating hormone, total thyroxin, Tg, and TgAb. Results: In the reference population, the median DBS-Tg was 9.2 μg/L (95% confidence interval, 8.7 to 9.8 μg/L) and was not significantly different among trimesters. The reference range was 0.3 to 43.5 μg/L. Over a range of iodine intake, the Tg concentrations were U-shaped. Within countries, the median DBS-Tg and the presence of elevated DBS-Tg did not differ significantly between all PW and PW who were TgAb-negative. Conclusions: A median DBS-Tg of ∼10 μg/L with The Journal of Clinical Endocrinology & Metabolism, 102 (1) ISSN:0021-972X ISSN:1945-7197 |
| Databáze: | OpenAIRE |
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