| Popis: |
The present study aims to target a cytotoxic drug, Berberine to tumor tissues specifically by the use of iron oxide nanoparticles and a nitro triazole compound, Sanazole which gets accumulated in hypoxic tumor tissue. Under in vitro conditions the nanoparticles complexed with Berberine and Sanazole showed higher cytotoxicity to tumor cells than either of the drugs and complexes of single individual compounds. The tumor-bearing animals treated with these nanoparticle-drug complexes increased the regression in tumor volume and survival of the animals. The present work thus revealed the potential applications of Berberine and Sanazole in cancer therapy. |
