Flaxseed Effects on Inflammation Regulatory Gene Expressions in an Obese Animal Model
| Autor: | Michael A Mann, Yeong Rhee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Adipose tissue Inflammation 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Internal medicine medicine Omega 3 fatty acid 030109 nutrition & dietetics Adiponectin business.industry 04 agricultural and veterinary sciences 040401 food science Secoisolariciresinol diglucoside IκBα Cytokine Endocrinology chemistry Chemistry (miscellaneous) medicine.symptom business Weight gain Food Science |
| Zdroj: | Plant Foods for Human Nutrition. 76:292-296 |
| ISSN: | 1573-9104 0921-9668 |
| Popis: | Obesity is known to be partially influenced by low-grade inflammation caused by pro-inflammatory cytokines and excess adipose tissue. Flaxseed contains secoisolariciresinol diglucoside (SDG) and α-linolenic acid (ALA) that have been shown to prevent pro-inflammatory cytokine production and secretion. This study determined flaxseed effects on inflammation regulatory gene expressions and their relationships with weight gain in an obese animal model. C57BL/6J mice were fed with whole flaxseed, defatted flaxseed, or flaxseed oil supplemented high-fat diet for eight weeks. After eight weeks of dietary treatment, NF-κB, IκBα, IKKβ, IL-6, TNF-α, Akt2, and adiponectin gene expressions were measured. The result shows how health-promoting compounds in flaxseed assist in alleviating and preventing obesity-induced low-grade inflammation by actively working against IKKβ/NF-κB pathway. |
| Databáze: | OpenAIRE |
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