Induction of T Lymphocyte Responses to a Small Molecular Weight Antigen
| Autor: | Wesley W. Bullock, David H. Katz, Baruj Benacerraf |
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| Rok vydání: | 1975 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 115:272-277 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.115.1.272 |
| Popis: | 2,4-Dinitrophenyl (DNP) coupled to the copolymer D-glutamic acid and D-lysine (D-GL) induces B cell tolerance but not T cell tolerance. This implies either a lack of DNP determinant recognition by T cells or a substantial difference in tolerance mechanisms for the two cell types. In the present study D-GL was conjugated with the well-defined determinant azobenzenearsonate (ABA) coupled to single amino acids shown here and previously by others to trigger effectively T lymphocytes. The experiments presented here demonstrate that these ABA conjugates of D-GL, although capable of diminishing anti-ABA antibody production, completely fail to render ABA-specific T lymphocytes tolerant thus drawing us to conclude that there are significant operational differences in the mechanisms of tolerance induction in T and B lymphocytes, respectively. |
| Databáze: | OpenAIRE |
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