Alteration of organized structure of biofilm formed byStaphylococcus epidermidis on soft contact lenses
| Autor: | Roberto Perilli, Giuseppe Formisano, G Scorcia, Lucilla Baldassarri, S. Caiazza, Maria Luisa Marziano |
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| Rok vydání: | 2000 |
| Předmět: |
Micrococcaceae
biology Strain (chemistry) Chemistry medicine.medical_treatment Biomedical Engineering Biofilm Eye drop Diclofenac Sodium biochemical phenomena metabolism and nutrition biology.organism_classification Microbiology Biomaterials Contact lens stomatognathic diseases Diclofenac Staphylococcus epidermidis medicine medicine.drug |
| Zdroj: | Journal of Biomedical Materials Research. 49:53-57 |
| ISSN: | 1097-4636 0021-9304 |
| Popis: | The effect of a nonsteroidal antiinflammatory drug commercially available in eye drop form (sodium diclofenac) was assayed for its ability to affect biofilms formed by clinical Staphylococcus epidermidis isolates. Biofilms produced by one strain positive for a slime-associated antigen, suggested to be expressed by more virulent strains, was not affected by sodium diclofenac treatment. On the other hand, biofilm produced by the slime-positive, antigen-negative strain showed dramatic alterations already after short treatments with sodium diclofenac as reported for salicylate and other nonsteroidal drugs. Such results suggest further investigation of the possible use of sodium diclofenac drops in the treatment of ophthalmic infections in soft contact lens wearers. |
| Databáze: | OpenAIRE |
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