Study of Liver Function in Infants with Atopic Dermatitis Using the 13C-Methacetin Breath Test

Autor:	Yoji Iikura, Ayami Iwasaki, Toshikazu Tsubaki, Akira Akasawa, Takebumi Onda, Toshio Katsunuma, Katsushi Miura, Motohiro Ebisawa, Hirohisa Saito, Niroku Koya, Masahiro Kajiwara
Rok vydání:	1995
Předmět:	Breath test Allergy medicine.diagnostic_test business.industry Immunology General Medicine Atopic dermatitis medicine.disease Intestinal absorption Transaminase Excretion medicine Immunology and Allergy Liver function business Liver function tests
Zdroj:	International Archives of Allergy and Immunology. 107:189-193
ISSN:	1423-0097 1018-2438
DOI:	10.1159/000236973
Popis:	Serum glutamic-oxaloacetic transaminase (GOT) levels were determined in 214 infants (133 males and 81 females) with atopic dermatitis during their first visit to the Department of Allergy, National Children's Hospital, Tokyo, Japan. Compared with the normal hospital range, their levels were found to be significantly higher, a tendency which was more conspicuous in lower age groups. We carried out a 13C-methacetin breath test (MBT), administering the stable-isotope-labeled compound to 11 children with higher serum GOT values and 5 within the normal range to investigate hepatic metabolism of methacetin in infants with atopic dermatitis. 13C-methacetin was given orally, and the 13CO2 level in the breath was determined immediately before and after administration, by mass spectrometry. Compared to the normal controls, the atopic infants demonstrated significantly lower 13CO2 peak excretion and delayed peak time. The clearance rate of 13CO2 was also decreased. These results suggest some relationship between atopic dermatitis and liver function in infants.
Databáze:	OpenAIRE
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