Efficient Preparation of a Key Intermediate in the Synthesis of Roxifiban by Enzymatic Dynamic Kinetic Resolution on Large Scale

Autor:	Edward Gorko, John A Blackwell, J. C. Chung, Lakisha Powell, Charlotte E. Silverman, Lin-hua Zhang, Jaan A. Pesti, Pat N. Confalone, Joseph M. Fortunak, Mary Cooke, Robert E. Waltermire, Anzalone Luigi, Jinguao Yin, Philip Ma, Michael D. Hrytsak, Charles Ray
Rok vydání:	2003
Předmět:	chemistry.chemical_classification Reaction conditions Pilot plant Chemistry Computational chemistry Yield (chemistry) Organic Chemistry Physical and Theoretical Chemistry Thioester Kinetic resolution
Zdroj:	Organic Process Research & Development. 8:22-27
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op0300239
Popis:	Additional information is presented for the transformation of a kinetic resolution into a dynamic kinetic resolution of the isobutyl ester 5b to form the acid 2 in high yield and ee via the intermediacy of a thioester 6c, (Pesti, J. A.; Yin, J.; Zhang, L.-H; Anzalone, L. J. Am. Chem. Soc. 2001, 123, 11075−11076.). The development of optimized reaction conditions for the preparation of 6c, its dynamic kinetic resolution to 2, and the scale-up of both reactions into a pilot plant are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6755e5729f7f4c1368722f1f762c3a85 https://doi.org/10.1021/op0300239 Zobrazit plný text záznamu