Physical and in-vitro evaluation of pure and substituted MxCe1-xO2 (M = Co, Fe or Ti and x = 0.05) magnetic nanoparticles
| Autor: | S.K. Alla, Madaswamy S Muthu, Pratap Kollu, Nand Kishore Prasad, Matte Kasi Viswanadh, K. Neogi, A. Gangwar, S.K. Shaw, Nidhi Gupta, Rajiv Kumar Mandal, Sher Singh Meena |
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| Rok vydání: | 2021 |
| Předmět: |
010302 applied physics
Materials science Biocompatibility Dopant Process Chemistry and Technology Doping Nanoparticle 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Magnetization symbols.namesake 0103 physical sciences Materials Chemistry Ceramics and Composites symbols Magnetic nanoparticles Viability assay 0210 nano-technology Raman spectroscopy Nuclear chemistry |
| Zdroj: | Ceramics International. 47:8812-8819 |
| ISSN: | 0272-8842 |
| DOI: | 10.1016/j.ceramint.2020.12.001 |
| Popis: | High resolution TEM studies revealed the spherical morphology of MxCe1-xO2 (M = Co, Fe or Ti, x = 0.05) particles with their size in the range of 8–11 nm. Raman, UV and PL spectroscopy analyses evidenced that oxygen vacancy concentration modified with the type of dopants. The concentration of vacancies in the Co0.05Ce0.95O2 sample was relatively higher and hence it had optimum magnetization value. The in-vitro cytotoxicity study for MxCe1-xO2 (M = Co, Fe or Ti, x = 0.05) nanoparticles against human lung adenocarcinoma (A549 cells) was conducted. The results suggested that at a 10 μg/mL concentration, the undoped CeO2 nanoparticles have shown cell viability up to 99%. In contrast, at the same concentration, the doped CeO2 such as Co0.05Ce0.95O2, Fe0.05Ce0.95O2 and Ti0.05Ce0.95O2 nanoparticles demonstrated the cell viability of ~97%. Furthermore, the samples displayed reliable biocompatibility up to 1000 μg/mL concentration. Interestingly, Co-doped CeO2 nanoparticles exhibited relatively higher biocompatibility against A549 cells at all concentrations. Further, the higher amount of vacancies might have improved the free radical scavenging effect and so the biocompatibility for the samples. |
| Databáze: | OpenAIRE |
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