Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: The tropical perspective
| Autor: | Liew Woei Kang, Ong Seow Theng, Wong Kang Ning, A.C. Angus, Gao Yun Feng, Kavita Reginald, Bi Xue Zhi, Tiong Yuen Seng, Ong Tan Ching, Mona Kidon, Chew Fook Tim, Chiang Wen Chin, Shang Hui Shen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Allergy
biology business.industry Immunology Atopic dermatitis medicine.disease Immunoglobulin E biology.organism_classification Atopy medicine.anatomical_structure Immunopathology Pediatrics Perinatology and Child Health biology.protein Mite Immunology and Allergy Medicine business Sensitization Asthma |
| Zdroj: | Pediatric Allergy and Immunology. 22:202-210 |
| ISSN: | 0905-6157 |
| DOI: | 10.1111/j.1399-3038.2010.01094.x |
| Popis: | Sensitization to perennial aeroallergens correlates with the risk of persistent asthma (AS) in children. In tropical Singapore, multiple codominant species of mites abound in the indoor environment, and preferential species-specific sensitization has been associated with different phenotypes of allergic disease. We investigated the pattern of mite component-specific IgE (mcsIgE) in children with different phenotypes of clinical allergic disease in an environment with multiple mite species exposure. A prospective evaluation of newly diagnosed patients with clinical diagnosis of allergic rhinitis (AR), atopic dermatitis (AD), or AS and sensitization to one or more aeroallergens were performed. Sera were tested for specific IgE against an extensive panel of Dermatophagoides pteronyssinus and Blomia tropicalis allergens. A total of 253 children were included, mean age 7.3 yr, 79% fulfilled criteria for AR, 46% AS, 71% AD, and 31% for all three. Sensitization to one or both mites was observed in 91% of children, 89% were sensitized to D. pteronyssinus, and 70% to B. tropicalis. The most common mite allergens recognized by these atopic children were Der p 1 (64%), Der p 2 (71%), Blo t 5 (45%), Blo t 7 (44%), and Blo t 21 (56%). Specific IgE responses to an increased number of distinct mite allergens correlated with the complexity of the allergic phenotype. In multivariate analysis, an increased risk for the multi-systemic phenotype (AR + AS + AD) was associated with sensitization to an increased repertoire of mite components (three or more) (OR 4.3, 95% CI 2.1-8.8, p = 0.001) and a positive parental history of AS (OR 2.4, 95% CI 1.2-2.9, p = 0.013). A highly pleiomorphic IgE response to the prevalent indoor mites is associated with the presence of a multi-systemic allergic phenotype in childhood in a tropical environment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|