14α-Hydroxylation of steroids by mycelium of the mold fungus Curvularia lunata (VKPM F-981) to produce precursors for synthesizing new steroidal drugs

Autor:	O. A. Zeinalov, V. A. Andryushina, N. E. Voishvillo, A. V. Druzhinina, V. V. Yaderets, T. S. Stytsenko, M. A. Petrosyan
Rok vydání:	2013
Předmět:	Pharmacology biology Stereochemistry Pregnane Substrate (chemistry) Proligestone Fungus biology.organism_classification Hydroxylation chemistry.chemical_compound Transformation (genetics) chemistry Drug Discovery Androstane Mycelium
Zdroj:	Pharmaceutical Chemistry Journal. 47:103-108
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-013-0905-6
Popis:	Five 14α-hydroxylated derivatives of androstane and pregnane steroids were obtained using mycelium of the mold fungus Curvularia lunata (VKPM F-981). The conditions for microbiological transformation of androst-4-en-3,17-dione that enabled its 14α-hydroxy analog to be obtained in yields up to 60% with substrate loading 6 g/L were determined. The 21-acetoxy analog of proligestone was synthesized from 14α-hydroxycortexolone that was formed simultaneously with hydrocortisone during hydroxylation of cortexolone by C. lunata. The resulting 14α- and 14α,21-hydroxysteroids could be used as precursors for the synthesis of new drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::673c79190109706ab25c483aad1a695f https://doi.org/10.1007/s11094-013-0905-6 Zobrazit plný text záznamu Plný text ve formátu PDF